Assay Detail
Functional
CHEMBL693553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration necessary to decrease extracellular Hepatitis B virus DNA levels by 50% in human hepatoblastoma cell line (2.2.15 cells) in vitro
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Robustaflavone, a naturally occurring biflavanoid, is a potent non-nucleoside inhibitor of hepatitis B virus replication in vitro
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.65 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.42 |
| CHEMBL1540 | PENCICLOVIR | 4.0 | 1 | 6.72 |
| CHEMBL63677 | ROBUSTAFLAVONE | — | 1 | 6.60 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141 | LAMIVUDINE | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1540 | PENCICLOVIR | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL63677 | ROBUSTAFLAVONE | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 1400.0 | nM | 5.85 |