Assay Detail
Functional
CHEMBL693668
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Inhibitory concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.21 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146673 | (NORTH)-METHANOCARBATHYMIDINE | 1.0 | 1 | 7.40 |
| CHEMBL413063 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146673 | (NORTH)-METHANOCARBATHYMIDINE | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL413063 | — | EC50 | = | 95.0 | nM | 7.02 |