Assay Detail
Functional
CHEMBL693798
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Concentration required to inhibit cholesterol synthesis in Hep G2 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.52 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130431 | — | — | 1 | 9.05 |
| CHEMBL336939 | — | — | 1 | 8.89 |
| CHEMBL131147 | — | — | 1 | 8.89 |
| CHEMBL414430 | — | — | 1 | 8.82 |
| CHEMBL436588 | — | — | 1 | 8.80 |
| CHEMBL132100 | — | — | 1 | 8.77 |
| CHEMBL338582 | — | — | 1 | 8.72 |
| CHEMBL131335 | — | — | 1 | 8.70 |
| CHEMBL335456 | — | — | 1 | 8.66 |
| CHEMBL441322 | — | — | 1 | 8.62 |
| CHEMBL335394 | — | — | 1 | 8.62 |
| CHEMBL130767 | — | — | 1 | 8.60 |
| CHEMBL337655 | — | — | 1 | 8.44 |
| CHEMBL40991 | ZARAGOZIC ACID A | — | 1 | 8.22 |
| CHEMBL337256 | — | — | 1 | 8.12 |
| CHEMBL334791 | — | — | 1 | 8.10 |
| CHEMBL337434 | — | — | 1 | 8.06 |
| CHEMBL130012 | — | — | 1 | 8.02 |
| CHEMBL262441 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130431 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL336939 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL131147 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL414430 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL436588 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL132100 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL338582 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL131335 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL335456 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL441322 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL335394 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL130767 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL337655 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL40991 | ZARAGOZIC ACID A | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL337256 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL334791 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL337434 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL130012 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL262441 | — | IC50 | = | 14.0 | nM | 7.85 |