Assay Detail
Functional
CHEMBL693811
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Compound was tested for inhibition of cholesterol biosynthesis in HepG2 cells from [14C]- acetate
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.77 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279569 | — | — | 1 | 8.00 |
| CHEMBL17470 | — | — | 1 | 7.16 |
| CHEMBL17168 | — | — | 1 | 6.16 |
| CHEMBL122299 | — | — | 1 | 5.70 |
| CHEMBL119316 | — | — | 1 | 5.55 |
| CHEMBL333562 | — | — | 1 | 4.72 |
| CHEMBL308982 | — | — | 1 | 4.55 |
| CHEMBL120689 | — | — | 1 | 4.28 |
| CHEMBL331432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279569 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL17470 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL17168 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL122299 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL119316 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL333562 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL308982 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL120689 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL331432 | — | IC50 | > | 100000.0 | nM | - |