Assay Detail
Binding
CHEMBL693825
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Compound is evaluated for in vitro receptor binding affinity against H1 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.10 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338611 | — | — | 1 | 7.36 |
| CHEMBL305660 | EBASTINE | 4.0 | 1 | 7.35 |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 7.03 |
| CHEMBL553331 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338611 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL305660 | EBASTINE | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL17157 | TERFENADINE | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL553331 | — | IC50 | = | 220.0 | nM | 6.66 |