Assay Detail
Functional
CHEMBL693827
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In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileum
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally-restricted ligands for the histamine H1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.37 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280432 | — | — | 1 | 7.97 |
| CHEMBL23897 | — | — | 1 | 7.77 |
| CHEMBL283169 | — | — | 1 | 7.64 |
| CHEMBL23638 | — | — | 1 | 7.58 |
| CHEMBL22215 | — | — | 1 | 7.55 |
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 7.47 |
| CHEMBL278398 | PHENINDAMINE | 2.0 | 1 | 7.44 |
| CHEMBL279297 | — | — | 1 | 7.28 |
| CHEMBL281638 | — | — | 1 | 6.66 |
| CHEMBL279454 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280432 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL23897 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL283169 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL23638 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL22215 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL511 | PYRILAMINE | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL278398 | PHENINDAMINE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL279297 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL281638 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL279454 | — | IC50 | = | 470.0 | nM | 6.33 |