Assay Detail
Binding
CHEMBL693832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and antiallergy activity of 4-(diarylhydroxymethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.05 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17436 | — | — | 1 | 8.10 |
| CHEMBL17390 | — | — | 1 | 7.38 |
| CHEMBL17237 | — | — | 1 | 7.20 |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 6.53 |
| CHEMBL555593 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17436 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL17390 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL17237 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL17157 | TERFENADINE | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL555593 | — | IC50 | = | 956.0 | nM | 6.02 |