Assay Detail
Functional
CHEMBL693870
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of cell growth of HT-29 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological activity of combretastatin analogues. Naphthylcombretastatins and related compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.44 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.30 |
| CHEMBL78126 | — | — | 1 | 6.52 |
| CHEMBL74611 | — | — | 1 | 5.24 |
| CHEMBL309050 | — | — | 1 | 5.23 |
| CHEMBL306334 | — | — | 1 | 5.20 |
| CHEMBL307158 | — | — | 1 | 4.82 |
| CHEMBL77735 | — | — | 1 | 4.64 |
| CHEMBL77453 | — | — | 1 | 4.53 |
| CHEMBL74417 | — | — | 1 | - |
| CHEMBL73140 | — | — | 1 | - |
| CHEMBL77321 | — | — | 1 | - |
| CHEMBL264619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL78126 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL74611 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL309050 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL306334 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL307158 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL77735 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL77453 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL74417 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL73140 | — | IC50 | > | 41200.0 | nM | - |
| CHEMBL77321 | — | IC50 | > | 28700.0 | nM | - |
| CHEMBL264619 | — | IC50 | > | 28900.0 | nM | - |