Assay Detail
Functional
CHEMBL693874
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Inhibitory activity against HT-29 human colon adenocarcinoma cells was determined.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of 7-substituted 3-(2, 6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective inhibitors of pp60(c-src).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.95 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104779 | — | — | 1 | 6.85 |
| CHEMBL106772 | — | — | 1 | 6.70 |
| CHEMBL51283 | — | — | 1 | 6.62 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 6.55 |
| CHEMBL107277 | — | — | 1 | 6.12 |
| CHEMBL104414 | — | — | 1 | 6.08 |
| CHEMBL108333 | — | — | 1 | 5.80 |
| CHEMBL108004 | — | — | 1 | 5.72 |
| CHEMBL108013 | — | — | 1 | 5.66 |
| CHEMBL107071 | — | — | 1 | 5.55 |
| CHEMBL106839 | — | — | 1 | 5.43 |
| CHEMBL107472 | — | — | 1 | 5.39 |
| CHEMBL299194 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104779 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL106772 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL51283 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL107277 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL104414 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL108333 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL108004 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL108013 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL107071 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL106839 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL107472 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL299194 | — | IC50 | = | 15000.0 | nM | 4.82 |