Assay Detail
Functional
CHEMBL694005
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antiviral activity in Human cytomegalovirus by plaque assay (HCMV)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.80 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143101 | — | — | 1 | 7.60 |
| CHEMBL3143102 | — | — | 1 | 6.66 |
| CHEMBL473686 | — | — | 1 | 6.00 |
| CHEMBL2111874 | — | — | 1 | 5.50 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.13 |
| CHEMBL2112687 | — | — | 1 | 4.92 |
| CHEMBL2112691 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143101 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3143102 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL473686 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2111874 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2112687 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2112691 | — | IC50 | = | 16000.0 | nM | 4.80 |