Assay Detail
Binding
CHEMBL694123
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Inhibitory activity was evaluated in vitro against HIV- I reverse transcriptase (RT)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of a conformationally constrained analog of the bis(heteroaryl)piperazine (BHAP) HIV-1 reverse transcriptase inhibitor atevirdine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.62 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | 5.96 |
| CHEMBL7264 | ATEVIRDINE SULPHATE | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL929 | DELAVIRDINE MESYLATE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL7264 | ATEVIRDINE SULPHATE | IC50 | = | 5200.0 | nM | 5.28 |