Assay Detail
Functional
CHEMBL694146
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant against HSV-1 TK
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | herpes simplex virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.89 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL788 | IDOXURIDINE | 4.0 | 1 | 7.05 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 7.00 |
| CHEMBL52609 | DOXRIBTIMINE | 2.0 | 1 | 6.70 |
| CHEMBL2311131 | — | — | 1 | 6.68 |
| CHEMBL341644 | — | — | 1 | 6.66 |
| CHEMBL146673 | (NORTH)-METHANOCARBATHYMIDINE | 1.0 | 1 | 4.79 |
| CHEMBL413063 | — | — | 1 | 4.16 |
| CHEMBL344107 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL788 | IDOXURIDINE | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL31634 | BRIVUDINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL52609 | DOXRIBTIMINE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2311131 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL341644 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL146673 | (NORTH)-METHANOCARBATHYMIDINE | Ki | = | 16100.0 | nM | 4.79 |
| CHEMBL413063 | — | Ki | = | 69800.0 | nM | 4.16 |
| CHEMBL344107 | — | Ki | = | 85800.0 | nM | 4.07 |