Assay Detail
Functional
CHEMBL694149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dose required to inhibit cell growth was determined against HT-29 cell line of human adenocarcinoma
34
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antimitotic antitumor agents: synthesis, structure-activity relationships, and biological characterization of N-aryl-N'-(2-chloroethyl)ureas as new selective alkylating agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.79 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358165 | — | — | 1 | 5.44 |
| CHEMBL357489 | — | — | 1 | 5.41 |
| CHEMBL356033 | — | — | 1 | 5.30 |
| CHEMBL160114 | — | — | 1 | 5.27 |
| CHEMBL148690 | — | — | 1 | 5.26 |
| CHEMBL159697 | — | — | 1 | 5.19 |
| CHEMBL161784 | — | — | 1 | 5.05 |
| CHEMBL146303 | — | — | 1 | 5.04 |
| CHEMBL149175 | — | — | 1 | 5.00 |
| CHEMBL164268 | — | — | 1 | 4.92 |
| CHEMBL159887 | — | — | 1 | 4.92 |
| CHEMBL146268 | — | — | 1 | 4.89 |
| CHEMBL348741 | — | — | 1 | 4.85 |
| CHEMBL513 | CARMUSTINE | 4.0 | 1 | 4.77 |
| CHEMBL159809 | — | — | 1 | 4.70 |
| CHEMBL346689 | — | — | 1 | 4.68 |
| CHEMBL161012 | — | — | 1 | 4.68 |
| CHEMBL353576 | — | — | 1 | 4.66 |
| CHEMBL161374 | — | — | 1 | 4.64 |
| CHEMBL162017 | — | — | 1 | 4.64 |
| CHEMBL159599 | — | — | 1 | 4.62 |
| CHEMBL159685 | — | — | 1 | 4.60 |
| CHEMBL349619 | — | — | 1 | 4.48 |
| CHEMBL349708 | — | — | 1 | 4.46 |
| CHEMBL163103 | — | — | 1 | 4.44 |
| CHEMBL348361 | — | — | 1 | 4.42 |
| CHEMBL159393 | — | — | 1 | 4.32 |
| CHEMBL163183 | — | — | 1 | 4.12 |
| CHEMBL159826 | — | — | 2 | 4.08 |
| CHEMBL160067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358165 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL357489 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL356033 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL160114 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL148690 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL159697 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL161784 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL146303 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL149175 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL164268 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL159887 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL146268 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL348741 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL513 | CARMUSTINE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL159809 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL346689 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL161012 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL353576 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL161374 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL162017 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL159599 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL159685 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL349619 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL349708 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL163103 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL348361 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL159393 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL163183 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL159826 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL160067 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL159395 | — | IC50 | = | 132000.0 | nM | - |
| CHEMBL161329 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL515 | CHLORAMBUCIL | IC50 | > | 100000.0 | nM | - |
| CHEMBL159826 | — | IC50 | = | - | nM | - |