Assay Detail

CHEMBL694206

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibitory activity against HeLa cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT, Sigma) assay.

ChEMBL ↗

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Target

HeLa (CHEMBL399) ↗

Open DB target context

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Primary target HeLa

CHEMBL399

Anchored from Assay target.

Protein identity HeLa

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HeLa
Confidence	1 — Organism
Curated By	Intermediate

Target

HeLa (CHEMBL399) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Triethylene tetraamine: a novel telomerase inhibitor.

Yin F, Liu J, Peng X.
Bioorg Med Chem Lett (2003) 13 : 3923 -3926
PubMed 14592476 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	4.62	5.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL609	TRIENTINE	4.0	2	5.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL609	TRIENTINE	IC50	=	7800.0	nM	5.11
CHEMBL609	TRIENTINE	IC50	=	74800.0	nM	4.13