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Assay Detail

CHEMBL694279

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Binding
In vitro inhibitory activity against human leukocyte elastase was determined
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Neutrophil elastase (CHEMBL248)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Examination of peptidic ,-diamino-,-difluoroketones as inhibitors of human leukocyte elastase
Bernstein PR, Kosmider B, Vacek E, Veale C, Gomes B
Bioorg Med Chem Lett (1994) 4 : 2175 -2178
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 8.69 9.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL432539 1 9.46
CHEMBL302961 1 9.42
CHEMBL306202 1 9.41
CHEMBL68311 1 9.19
CHEMBL66128 1 9.09
CHEMBL304114 1 9.07
CHEMBL306203 1 8.96
CHEMBL68577 1 8.80
CHEMBL417935 1 8.64
CHEMBL354883 1 8.60
CHEMBL308415 1 8.52
CHEMBL55210 1 8.51
CHEMBL306877 1 8.47
CHEMBL302123 1 8.47
CHEMBL305259 1 8.39
CHEMBL306676 1 7.82
CHEMBL306105 1 6.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL432539 Ki = 0.35 nM 9.46
CHEMBL302961 Ki = 0.38 nM 9.42
CHEMBL306202 Ki = 0.39 nM 9.41
CHEMBL68311 Ki = 0.65 nM 9.19
CHEMBL66128 Ki = 0.81 nM 9.09
CHEMBL304114 Ki = 0.85 nM 9.07
CHEMBL306203 Ki = 1.1 nM 8.96
CHEMBL68577 Ki = 1.6 nM 8.80
CHEMBL417935 Ki = 2.3 nM 8.64
CHEMBL354883 Ki = 2.5 nM 8.60
CHEMBL308415 Ki = 3.0 nM 8.52
CHEMBL55210 Ki = 3.1 nM 8.51
CHEMBL306877 Ki = 3.4 nM 8.47
CHEMBL302123 Ki = 3.4 nM 8.47
CHEMBL305259 Ki = 4.1 nM 8.39
CHEMBL306676 Ki = 15.0 nM 7.82
CHEMBL306105 Ki = 130.0 nM 6.89