Assay Detail
Binding
CHEMBL694281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ratio of Koff to that of Kon was determined on human leukocyte elastase(HLE)
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The design of potent and stable benzisothiazolone inhibitors of human leukocyte elastase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 9.01 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115827 | — | — | 1 | 10.64 |
| CHEMBL325155 | — | — | 1 | 10.52 |
| CHEMBL314218 | — | — | 1 | 10.52 |
| CHEMBL112575 | — | — | 1 | 9.70 |
| CHEMBL98422 | — | — | 1 | 9.57 |
| CHEMBL50974 | — | — | 1 | 9.52 |
| CHEMBL50830 | — | — | 1 | 9.22 |
| CHEMBL319723 | — | — | 1 | 9.22 |
| CHEMBL299656 | — | — | 1 | 9.15 |
| CHEMBL333152 | — | — | 1 | 8.96 |
| CHEMBL296159 | — | — | 1 | 8.70 |
| CHEMBL100620 | — | — | 1 | 8.70 |
| CHEMBL323694 | — | — | 1 | 8.66 |
| CHEMBL112205 | — | — | 1 | 8.28 |
| CHEMBL432890 | — | — | 1 | 7.85 |
| CHEMBL323545 | — | — | 1 | 7.84 |
| CHEMBL50803 | — | — | 1 | 7.82 |
| CHEMBL298107 | — | — | 1 | 7.22 |
| CHEMBL300430 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115827 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL325155 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL314218 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL112575 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL98422 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL50974 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL50830 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL319723 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL299656 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL333152 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL296159 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL100620 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL323694 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL112205 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL432890 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL323545 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL50803 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL298107 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL300430 | — | Ki | > | 2000.0 | nM | - |