Assay Detail
Binding
CHEMBL694282
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Ratio of Kreact to that of Kinact was determined on human leukocyte elastase(HLE)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of human leukocyte elastase. 3.1 inhibition by tetrahydrobenzisothiazolinylmethyl aryl carboxylates
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.82 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314218 | — | — | 1 | 10.52 |
| CHEMBL3085439 | — | — | 1 | 9.40 |
| CHEMBL326848 | — | — | 1 | 9.15 |
| CHEMBL326847 | — | — | 1 | 9.10 |
| CHEMBL114017 | — | — | 1 | 9.00 |
| CHEMBL112119 | — | — | 1 | 9.00 |
| CHEMBL326136 | — | — | 1 | 9.00 |
| CHEMBL112514 | — | — | 1 | 8.30 |
| CHEMBL113688 | — | — | 1 | 7.75 |
| CHEMBL111852 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314218 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL3085439 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL326848 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL326847 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL114017 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL112119 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL326136 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL112514 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL113688 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL111852 | — | Ki | = | 100.0 | nM | 7.00 |