Assay Detail
Functional
CHEMBL694310
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The compound was tested for cytotoxic activity against HT-29 cell line(human colon adeno carcinoma)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N4-(omega-Aminoalkyl)-1-[(omega-aminoalkyl)amino]-4- acridinecarboxamides: novel, potent, cytotoxic, and DNA-binding agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.29 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104423 | — | — | 1 | 8.15 |
| CHEMBL146276 | — | — | 1 | 7.00 |
| CHEMBL145082 | — | — | 1 | 6.36 |
| CHEMBL358134 | — | — | 1 | 6.25 |
| CHEMBL342800 | — | — | 1 | 6.24 |
| CHEMBL535811 | — | — | 1 | 6.16 |
| CHEMBL1794954 | — | — | 1 | 6.15 |
| CHEMBL145573 | — | — | 1 | 6.10 |
| CHEMBL145428 | — | — | 1 | 6.07 |
| CHEMBL144975 | — | — | 1 | 5.57 |
| CHEMBL144470 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104423 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL146276 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL145082 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL358134 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL342800 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL535811 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1794954 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL145573 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL145428 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL144975 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL144470 | — | IC50 | = | 6940.0 | nM | 5.16 |