Assay Detail
Functional
CHEMBL694339
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Concentration required to kill hypoxic HT-29 human colon carcinoma cells in vitro
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.80 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436403 | — | — | 1 | 7.80 |
| CHEMBL144115 | — | — | 1 | 7.75 |
| CHEMBL344761 | — | — | 1 | 7.37 |
| CHEMBL423373 | — | — | 1 | 7.19 |
| CHEMBL143167 | — | — | 1 | 7.10 |
| CHEMBL342956 | — | — | 1 | 7.02 |
| CHEMBL144407 | — | — | 1 | 6.96 |
| CHEMBL145788 | — | — | 1 | 6.92 |
| CHEMBL144802 | — | — | 1 | 6.75 |
| CHEMBL144932 | — | — | 1 | 6.23 |
| CHEMBL144526 | — | — | 1 | 5.24 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436403 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL144115 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL344761 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL423373 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL143167 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL342956 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL144407 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL145788 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL144802 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL144932 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL144526 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 6200.0 | nM | 5.21 |