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Assay Detail

CHEMBL694342

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Functional
Cytotoxic activity against colon adenocarcinoma (HT-29) cell line
ChEMBL ↗
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Expert

Target

HT-29 (CHEMBL384) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis, cytotoxicity, and antitumor activity of copper(II) and iron(II) complexes of (4)N-azabicyclo[3.2.2]nonane thiosemicarbazones derived from acyl diazines.
Easmon J, Pürstinger G, Heinisch G, Roth T, Fiebig HH, Holzer W, Jäger W, Jenny M, Hofmann J.
J Med Chem (2001) 44 : 2164 -2171
PubMed 11405653 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.94 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL303030 N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 8.40
CHEMBL307750 N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 8.40
CHEMBL69491 — — 1 7.96
CHEMBL68899 — — 1 7.64
CHEMBL71931 N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 7.55
CHEMBL68043 — — 1 7.46
CHEMBL307351 — — 1 7.42
CHEMBL66382 — — 1 7.30
CHEMBL66328 Fe (II) complex — 1 7.22
CHEMBL69107 Fe (II) complex — 1 7.16
CHEMBL69122 Fe (II) complex — 1 6.40
CHEMBL308445 — — 1 6.31
CHEMBL305532 Fe (II) complex — 1 6.12
CHEMBL69031 Fe (II) complex — 1 6.11
CHEMBL67816 N-[(1E)-1-(6-methylpyridazin-3-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 6.06
CHEMBL68993 — — 1 5.86
CHEMBL68968 Copper(II) Complex — 1 5.82
CHEMBL68910 — — 1 5.65
CHEMBL66349 N-[(1E)-1-pyrazin-2-ylethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 -
CHEMBL69182 N-[(1E)-1-pyrimidin-4-ylethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL303030 N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 = 4.0 nM 8.40
CHEMBL307750 N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 = 4.0 nM 8.40
CHEMBL69491 — IC50 = 11.0 nM 7.96
CHEMBL68899 — IC50 = 23.0 nM 7.64
CHEMBL71931 N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 = 28.0 nM 7.55
CHEMBL68043 — IC50 = 35.0 nM 7.46
CHEMBL307351 — IC50 = 38.0 nM 7.42
CHEMBL66382 — IC50 = 50.0 nM 7.30
CHEMBL66328 Fe (II) complex IC50 = 60.0 nM 7.22
CHEMBL69107 Fe (II) complex IC50 = 70.0 nM 7.16
CHEMBL69122 Fe (II) complex IC50 = 400.0 nM 6.40
CHEMBL308445 — IC50 = 490.0 nM 6.31
CHEMBL305532 Fe (II) complex IC50 = 750.0 nM 6.12
CHEMBL69031 Fe (II) complex IC50 = 770.0 nM 6.11
CHEMBL67816 N-[(1E)-1-(6-methylpyridazin-3-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 = 870.0 nM 6.06
CHEMBL68993 — IC50 = 1370.0 nM 5.86
CHEMBL68968 Copper(II) Complex IC50 = 1510.0 nM 5.82
CHEMBL68910 — IC50 = 2220.0 nM 5.65
CHEMBL66349 N-[(1E)-1-pyrazin-2-ylethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 < 10.0 nM -
CHEMBL69182 N-[(1E)-1-pyrimidin-4-ylethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex IC50 < 10.0 nM -