Assay Detail
Functional
CHEMBL694354
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Inhibitory concentration against cholesterol biosynthesis in HepG2 cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of 2,3-oxidosqualene cyclase by N-alkylpiperidines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.25 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17168 | — | — | 1 | 9.15 |
| CHEMBL17239 | — | — | 1 | 7.92 |
| CHEMBL17737 | — | — | 1 | 7.40 |
| CHEMBL418176 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17168 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL17239 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL17737 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL418176 | — | IC50 | = | 30000.0 | nM | 4.52 |