Assay Detail
Functional
CHEMBL694355
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Tested for ability to inhibit the incorporation of [14C]- acetate in to cholesterol in HepG2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.08 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120932 | — | — | 1 | 8.28 |
| CHEMBL121756 | — | — | 1 | 8.15 |
| CHEMBL333307 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120932 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL121756 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL333307 | — | IC50 | = | 15.8 | nM | 7.80 |