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Assay Detail

CHEMBL694391

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Functional
Inhibitory activity against human carbonic anhydrase II using pH stat assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides.
Shepard KL, Graham SL, Hudcosky RJ, Michelson SR, Scholz TH, Schwam H, Smith AM, Sondey JM, Strohmaier KM, Smith RL.
J Med Chem (1991) 34 : 3098 -3105
PubMed 1920359 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 7.80 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL104754 1 8.82
CHEMBL104621 1 8.64
CHEMBL107437 1 8.52
CHEMBL322223 1 8.46
CHEMBL319397 1 8.40
CHEMBL319239 1 8.37
CHEMBL104868 1 8.35
CHEMBL320808 1 8.35
CHEMBL104929 1 8.30
CHEMBL104666 1 8.30
CHEMBL104442 1 8.26
CHEMBL104463 1 8.22
CHEMBL105725 1 8.22
CHEMBL105731 1 8.15
CHEMBL105637 1 8.10
CHEMBL107266 1 8.05
CHEMBL105607 1 8.05
CHEMBL107537 1 8.05
CHEMBL106683 1 8.00
CHEMBL104000 1 7.92
CHEMBL314569 1 7.89
CHEMBL316582 1 7.82
CHEMBL104630 1 7.75
CHEMBL321553 1 7.70
CHEMBL105688 1 7.70
CHEMBL104311 1 7.70
CHEMBL321889 1 7.70
CHEMBL105730 1 7.68
CHEMBL105691 1 7.64
CHEMBL108015 1 7.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL104754 IC50 = 1.5 nM 8.82
CHEMBL104621 IC50 = 2.3 nM 8.64
CHEMBL107437 IC50 = 3.0 nM 8.52
CHEMBL322223 IC50 = 3.5 nM 8.46
CHEMBL319397 IC50 = 4.0 nM 8.40
CHEMBL319239 IC50 = 4.3 nM 8.37
CHEMBL104868 IC50 = 4.5 nM 8.35
CHEMBL320808 IC50 = 4.5 nM 8.35
CHEMBL104929 IC50 = 5.0 nM 8.30
CHEMBL104666 IC50 = 5.0 nM 8.30
CHEMBL104442 IC50 = 5.5 nM 8.26
CHEMBL104463 IC50 = 6.0 nM 8.22
CHEMBL105725 IC50 = 6.0 nM 8.22
CHEMBL105731 IC50 = 7.0 nM 8.15
CHEMBL105637 IC50 = 8.0 nM 8.10
CHEMBL107266 IC50 = 9.0 nM 8.05
CHEMBL107537 IC50 = 9.0 nM 8.05
CHEMBL105607 IC50 = 9.0 nM 8.05
CHEMBL106683 IC50 = 10.0 nM 8.00
CHEMBL104000 IC50 = 12.0 nM 7.92
CHEMBL314569 IC50 = 13.0 nM 7.89
CHEMBL316582 IC50 = 15.0 nM 7.82
CHEMBL104630 IC50 = 18.0 nM 7.75
CHEMBL321553 IC50 = 20.0 nM 7.70
CHEMBL105688 IC50 = 20.0 nM 7.70
CHEMBL104311 IC50 = 20.0 nM 7.70
CHEMBL321889 IC50 = 20.0 nM 7.70
CHEMBL105730 IC50 = 21.0 nM 7.68
CHEMBL105691 IC50 = 23.0 nM 7.64
CHEMBL108015 IC50 = 23.0 nM 7.64
CHEMBL104459 IC50 = 24.0 nM 7.62
CHEMBL319238 IC50 = 25.0 nM 7.60
CHEMBL104961 IC50 = 30.0 nM 7.52
CHEMBL318951 IC50 = 30.0 nM 7.52
CHEMBL106848 IC50 = 37.0 nM 7.43
CHEMBL104524 IC50 = 51.0 nM 7.29
CHEMBL105573 IC50 = 64.0 nM 7.19
CHEMBL319437 IC50 = 700.0 nM 6.16
CHEMBL316814 IC50 = 900.0 nM 6.05
CHEMBL105380 IC50 = 10000.0 nM 5.00