Assay Detail
Binding
CHEMBL694463
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The binding affinity at the Histamine H1 receptor determined using [3H]pyrilamine
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.02 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.38 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 8.29 |
| CHEMBL111184 | — | — | 1 | 7.89 |
| CHEMBL113238 | — | — | 1 | 7.85 |
| CHEMBL334270 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL654 | MIRTAZAPINE | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL111184 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL113238 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL334270 | — | Ki | = | 21.0 | nM | 7.68 |