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Assay Detail

CHEMBL694494

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was evaluated for in vitro effective concentration against HRV serotype-14 (HRV-14)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus sp.
Confidence 1 — Organism
Curated By Intermediate

Target

Human rhinovirus sp. (CHEMBL612470)
Type ORGANISM
Organism Human rhinovirus sp.

Publication

Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors.
Dragovich PS, Zhou R, Webber SE, Prins TJ, Kwok AK, Okano K, Fuhrman SA, Zalman LS, Maldonado FC, Brown EL, Meador JW, Patick AK, Ford CE, Brothers MA, Binford SL, Matthews DA, Ferre RA, Worland ST.
Bioorg Med Chem Lett (2000) 10 : 45 -48
PubMed 10636240 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 5.31 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145753 1 6.47
CHEMBL95007 1 5.62
CHEMBL407772 1 5.50
CHEMBL359383 1 5.40
CHEMBL359166 1 5.10
CHEMBL356572 1 5.10
CHEMBL358959 1 4.77
CHEMBL145160 1 4.50
CHEMBL358554 1 -
CHEMBL145508 1 -
CHEMBL358738 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145753 EC50 = 340.0 nM 6.47
CHEMBL95007 EC50 = 2400.0 nM 5.62
CHEMBL407772 EC50 = 3200.0 nM 5.50
CHEMBL359383 EC50 = 4000.0 nM 5.40
CHEMBL359166 EC50 = 7900.0 nM 5.10
CHEMBL356572 EC50 = 7900.0 nM 5.10
CHEMBL358959 EC50 = 17000.0 nM 4.77
CHEMBL145160 EC50 = 32000.0 nM 4.50
CHEMBL358554 EC50 > 10000.0 nM -
CHEMBL145508 EC50 > 10000.0 nM -
CHEMBL358738 EC50 > 25000.0 nM -