Assay Detail
Functional
CHEMBL694511
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Compound was evaluated for mepyramine antagonism effects in guinea pig aorta (contraction) at a mepyramine concentration of 100 nM
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.79 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275507 | — | — | 2 | 9.01 |
| CHEMBL275035 | — | — | 1 | 8.75 |
| CHEMBL11553 | — | — | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275507 | — | Kd | = | 0.9772 | nM | 9.01 |
| CHEMBL275507 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL275035 | — | Kd | = | 1.778 | nM | 8.75 |
| CHEMBL11553 | — | Kd | = | 2.512 | nM | 8.60 |