Assay Detail
Functional
CHEMBL694514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of guinea pig ileum contraction at 100 nM mepyramine
8
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Histaprodifens: synthesis, pharmacological in vitro evaluation, and molecular modeling of a new class of highly active and selective histamine H(1)-receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 8.93 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275035 | — | — | 2 | 9.13 |
| CHEMBL275507 | — | — | 1 | 9.11 |
| CHEMBL11553 | — | — | 2 | 9.11 |
| CHEMBL274831 | — | — | 2 | 8.85 |
| CHEMBL11515 | — | — | 1 | 8.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275035 | — | Kd | = | 0.7413 | nM | 9.13 |
| CHEMBL275507 | — | Kd | = | 0.7762 | nM | 9.11 |
| CHEMBL11553 | — | Kd | = | 0.7762 | nM | 9.11 |
| CHEMBL275035 | — | Kd | = | 1.349 | nM | 8.87 |
| CHEMBL11553 | — | Kd | = | 1.38 | nM | 8.86 |
| CHEMBL274831 | — | Kd | = | 1.413 | nM | 8.85 |
| CHEMBL11515 | — | Kd | = | 1.549 | nM | 8.81 |
| CHEMBL274831 | — | Kd | = | 2.138 | nM | 8.67 |