Assay Detail
Functional
CHEMBL694517
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Contractile effects antagonized by mepyramine (0.3-100 nM) against Histamine H1 receptor in guinea pig ileum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 9.07 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313301 | — | — | 1 | 9.15 |
| CHEMBL26116 | — | — | 1 | 9.13 |
| CHEMBL87583 | — | — | 1 | 9.13 |
| CHEMBL88075 | — | — | 1 | 9.13 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 9.07 |
| CHEMBL24665 | — | — | 1 | 9.05 |
| CHEMBL86522 | — | — | 1 | 9.04 |
| CHEMBL88074 | — | — | 1 | 8.98 |
| CHEMBL314438 | — | — | 1 | 8.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313301 | — | Kd | = | 0.7079 | nM | 9.15 |
| CHEMBL26116 | — | Kd | = | 0.7413 | nM | 9.13 |
| CHEMBL87583 | — | Kd | = | 0.7413 | nM | 9.13 |
| CHEMBL88075 | — | Kd | = | 0.7413 | nM | 9.13 |
| CHEMBL90 | HISTAMINE | Kd | = | 0.8511 | nM | 9.07 |
| CHEMBL24665 | — | Kd | = | 0.8913 | nM | 9.05 |
| CHEMBL86522 | — | Kd | = | 0.912 | nM | 9.04 |
| CHEMBL88074 | — | Kd | = | 1.047 | nM | 8.98 |
| CHEMBL314438 | — | Kd | = | 1.202 | nM | 8.92 |