Assay Detail
Binding
CHEMBL694594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against drug-resistant HIV(G48V) mutant protease
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3' residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.29 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305458 | — | — | 1 | 7.69 |
| CHEMBL302958 | — | — | 1 | 7.15 |
| CHEMBL70388 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305458 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL302958 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL70388 | — | IC50 | = | 94.0 | nM | 7.03 |