Assay Detail
Functional
CHEMBL694657
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Tested in vitro against HIV-1 LAI from MT-4 cells using MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Syntheses of 4'-C-ethynyl-beta-D-arabino- and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosylpyrimidines and -purines and evaluation of their anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 7.40 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368072 | — | — | 1 | 9.52 |
| CHEMBL2012671 | — | — | 1 | 8.85 |
| CHEMBL322215 | — | — | 1 | 8.32 |
| CHEMBL607878 | — | — | 1 | 8.32 |
| CHEMBL2368083 | — | — | 1 | 7.96 |
| CHEMBL2012670 | — | — | 1 | 7.92 |
| CHEMBL2368082 | — | — | 1 | 7.52 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.42 |
| CHEMBL2368070 | — | — | 1 | 6.82 |
| CHEMBL2368076 | — | — | 1 | 6.47 |
| CHEMBL2368078 | — | — | 1 | 6.21 |
| CHEMBL2368074 | — | — | 1 | 5.64 |
| CHEMBL2368077 | — | — | 1 | 5.22 |
| CHEMBL2368081 | — | — | 1 | - |
| CHEMBL2368084 | — | — | 1 | - |
| CHEMBL2368079 | — | — | 1 | - |
| CHEMBL2368073 | — | — | 1 | - |
| CHEMBL2368075 | — | — | 1 | - |
| CHEMBL2368080 | — | — | 1 | - |
| CHEMBL2368071 | — | — | 1 | - |
| CHEMBL607510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368072 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2012671 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL322215 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL607878 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL2368083 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2012670 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2368082 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2368070 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2368076 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2368078 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2368074 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2368077 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2368081 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2368084 | — | EC50 | = | 117000.0 | nM | - |
| CHEMBL2368079 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2368073 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2368075 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2368080 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2368071 | — | EC50 | > | 360000.0 | nM | - |
| CHEMBL607510 | — | EC50 | > | 350000.0 | nM | - |