Assay Detail
Functional
CHEMBL694718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro effective concentration required to inhibit varicella zoster virus (VZV) replication in HFF cell line by plaque reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.64 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155623 | — | — | 1 | 5.48 |
| CHEMBL152335 | — | — | 1 | 4.41 |
| CHEMBL357549 | — | — | 1 | 4.35 |
| CHEMBL154409 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155623 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL152335 | — | EC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL357549 | — | EC50 | = | 44900.0 | nM | 4.35 |
| CHEMBL154409 | — | EC50 | = | 50100.0 | nM | 4.30 |