Assay Detail
Functional
CHEMBL694827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to reverse ACPD-induced inhibition of forskolin-stimulated cAMP formation in the human mGluR2 expressing non-neuronal cells.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.74 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39338 | — | — | 1 | 4.74 |
| CHEMBL166775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39338 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL166775 | — | IC50 | = | 171000.0 | nM | - |