Assay Detail
Binding
CHEMBL694900
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Tested for inhibitory concentration required to inhibit 50% of histone deacetylase (HDAC) purified from human T cell leukemia Jurkat cell
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Jurkat |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.43 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283931 | — | — | 1 | 7.41 |
| CHEMBL27556 | — | — | 1 | 7.36 |
| CHEMBL26844 | — | — | 1 | 6.62 |
| CHEMBL275380 | — | — | 1 | 6.51 |
| CHEMBL28280 | — | — | 1 | 6.08 |
| CHEMBL283439 | — | — | 1 | 5.96 |
| CHEMBL26158 | — | — | 1 | 5.82 |
| CHEMBL26518 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283931 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL27556 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL26844 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL275380 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL28280 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL283439 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL26158 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL26518 | — | IC50 | = | 2000.0 | nM | 5.70 |