Assay Detail
Binding
CHEMBL694901
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Inhibition of Histone deacetylase (HDAC)of HeLa nuclear extracts
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.70 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.00 |
| CHEMBL336935 | — | — | 1 | 6.12 |
| CHEMBL140525 | — | — | 1 | 6.01 |
| CHEMBL141909 | — | — | 1 | 5.40 |
| CHEMBL343717 | — | — | 1 | 5.36 |
| CHEMBL137875 | — | — | 1 | 4.30 |
| CHEMBL138293 | — | — | 1 | - |
| CHEMBL141885 | — | — | 1 | - |
| CHEMBL337584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL336935 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL140525 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL141909 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL343717 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL137875 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL138293 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL141885 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL337584 | — | IC50 | > | 100000.0 | nM | - |