Assay Detail
Binding
CHEMBL694903
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In vitro inhibitory activity against histone deacetylase (HDAC) isolated from HeLa nuclear extract
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.39 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.55 |
| CHEMBL114237 | — | — | 1 | 4.85 |
| CHEMBL344920 | — | — | 1 | 4.77 |
| CHEMBL136792 | — | — | 1 | - |
| CHEMBL137003 | — | — | 1 | - |
| CHEMBL264784 | — | — | 1 | - |
| CHEMBL344475 | — | — | 1 | - |
| CHEMBL136992 | — | — | 1 | - |
| CHEMBL137216 | — | — | 1 | - |
| CHEMBL137278 | — | — | 1 | - |
| CHEMBL137036 | — | — | 1 | - |
| CHEMBL341701 | — | — | 1 | - |
| CHEMBL112539 | — | — | 1 | - |
| CHEMBL422460 | — | — | 1 | - |
| CHEMBL137333 | — | — | 1 | - |
| CHEMBL137695 | — | — | 1 | - |
| CHEMBL137672 | — | — | 1 | - |
| CHEMBL423356 | — | — | 1 | - |
| CHEMBL137519 | — | — | 1 | - |
| CHEMBL137100 | — | — | 1 | - |
| CHEMBL343377 | — | — | 1 | - |
| CHEMBL324053 | — | — | 1 | - |
| CHEMBL138381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL114237 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL344920 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL136792 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL137003 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL264784 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL344475 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL136992 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL137216 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL137278 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL137036 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL341701 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL112539 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL422460 | — | IC50 | = | 650000.0 | nM | - |
| CHEMBL137333 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL137695 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL137672 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423356 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL137519 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL137100 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL343377 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL324053 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL138381 | — | IC50 | = | 121000.0 | nM | - |