Assay Detail
Binding
CHEMBL694933
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Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.68 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99661 | — | — | 1 | 8.85 |
| CHEMBL99392 | — | — | 1 | 8.70 |
| CHEMBL95881 | — | — | 1 | 8.68 |
| CHEMBL329977 | — | — | 1 | 7.42 |
| CHEMBL98748 | — | — | 1 | 7.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.92 |
| CHEMBL98428 | — | — | 1 | 6.18 |
| CHEMBL101105 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99661 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL99392 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL95881 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL329977 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL98748 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL98428 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL101105 | — | IC50 | > | 5000.0 | nM | - |