Assay Detail
Binding
CHEMBL694934
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Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.68 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317614 | — | — | 1 | 7.42 |
| CHEMBL328819 | — | — | 1 | 7.29 |
| CHEMBL317734 | — | — | 1 | 7.18 |
| CHEMBL318616 | — | — | 1 | 6.19 |
| CHEMBL327292 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317614 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL328819 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL317734 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL318616 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL327292 | — | IC50 | = | 5000.0 | nM | 5.30 |