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Assay Detail

CHEMBL694956

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against partially purified histone deacetylase of human leukemia K562 cells.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type K562
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives.
Suzuki T, Ando T, Tsuchiya K, Fukazawa N, Saito A, Mariko Y, Yamashita T, Nakanishi O.
J Med Chem (1999) 42 : 3001 -3003
PubMed 10425110 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.48 8.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 1 8.34
CHEMBL419716 1 5.66
CHEMBL101167 1 5.55
CHEMBL100282 1 5.34
CHEMBL27759 ENTINOSTAT 3.0 1 5.32
CHEMBL421589 1 5.22
CHEMBL321283 1 5.11
CHEMBL319375 1 4.40
CHEMBL321105 1 4.36
CHEMBL100631 1 -
CHEMBL99853 1 -
CHEMBL99835 1 -
CHEMBL100925 1 -
CHEMBL99737 1 -
CHEMBL62381 SODIUM BUTYRATE 2.0 1 -
CHEMBL317252 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN IC50 = 4.6 nM 8.34
CHEMBL419716 IC50 = 2200.0 nM 5.66
CHEMBL101167 IC50 = 2800.0 nM 5.55
CHEMBL100282 IC50 = 4600.0 nM 5.34
CHEMBL27759 ENTINOSTAT IC50 = 4800.0 nM 5.32
CHEMBL421589 IC50 = 6000.0 nM 5.22
CHEMBL321283 IC50 = 7700.0 nM 5.11
CHEMBL319375 IC50 = 40000.0 nM 4.40
CHEMBL321105 IC50 = 44000.0 nM 4.36
CHEMBL100631 IC50 > 100000.0 nM -
CHEMBL99853 IC50 > 100000.0 nM -
CHEMBL99835 IC50 > 100000.0 nM -
CHEMBL100925 IC50 > 100000.0 nM -
CHEMBL99737 IC50 > 100000.0 nM -
CHEMBL62381 SODIUM BUTYRATE IC50 = 140000.0 nM -
CHEMBL317252 IC50 > 100000.0 nM -