Assay Detail
Binding
CHEMBL694958
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Inhibitory activity against Histone deacetylase (HDAC) in K 562 erythroleukemia cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Heterocyclic ketones as inhibitors of histone deacetylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.93 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.47 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.00 |
| CHEMBL113303 | — | — | 1 | 6.96 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.70 |
| CHEMBL112148 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL113303 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL112148 | — | IC50 | = | 2900.0 | nM | 5.54 |