Assay Detail

CHEMBL695001

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibition of TNF-alpha release from LPS-stimulated human mononuclear cells

ChEMBL ↗

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Target

PBMC (CHEMBL613107) ↗

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Primary target PBMC

CHEMBL613107

Anchored from Assay target.

Protein identity PBMC

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PBMC
Confidence	1 — Organism
Curated By	Expert

Target

PBMC (CHEMBL613107) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Novel cyclic compounds as potent phosphodiesterase 4 inhibitors.

He W, Huang FC, Hanney B, Souness J, Miller B, Liang G, Mason J, Djuric S.
J Med Chem (1998) 41 : 4216 -4223
PubMed 9784096 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.57	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL134441	—	—	1	6.70
CHEMBL135621	—	—	1	6.70
CHEMBL63	ROLIPRAM	2.0	1	6.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL134441	—	IC50	=	200.0	nM	6.70
CHEMBL135621	—	IC50	=	200.0	nM	6.70
CHEMBL63	ROLIPRAM	IC50	=	500.0	nM	6.30