Assay Detail
Functional
CHEMBL695042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for induction of cellular death in Human lung H-460 tumor cell line in Propidium Iodide Monolayer Assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.92 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112192 | — | — | 1 | 6.82 |
| CHEMBL112385 | — | — | 1 | 6.30 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.76 |
| CHEMBL324797 | — | — | 1 | 5.63 |
| CHEMBL321632 | — | — | 1 | 5.51 |
| CHEMBL115488 | — | — | 1 | 5.48 |
| CHEMBL116173 | — | — | 1 | - |
| CHEMBL115360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112192 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL112385 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL324797 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL321632 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL115488 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL116173 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL115360 | — | IC50 | < | 10.0 | nM | - |