Assay Detail
Binding
CHEMBL695135
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Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) prepared from K562 erythroleukemia cells.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Histone deacetylase (HDAC1 and HDAC2) (CHEMBL2111429) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Trifluoromethyl ketones as inhibitors of histone deacetylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.78 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115812 | — | — | 1 | 8.04 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.00 |
| CHEMBL331158 | — | — | 1 | 6.52 |
| CHEMBL116702 | — | — | 1 | 6.51 |
| CHEMBL115011 | — | — | 1 | 6.42 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.70 |
| CHEMBL114724 | — | — | 1 | 5.66 |
| CHEMBL326529 | — | — | 1 | 5.58 |
| CHEMBL116023 | — | — | 1 | 5.55 |
| CHEMBL112148 | — | — | 1 | 5.54 |
| CHEMBL116900 | — | — | 1 | 5.54 |
| CHEMBL323647 | — | — | 1 | 5.52 |
| CHEMBL324819 | — | — | 1 | 5.50 |
| CHEMBL117916 | — | — | 1 | 5.47 |
| CHEMBL323652 | — | — | 1 | 5.34 |
| CHEMBL424256 | — | — | 1 | 5.30 |
| CHEMBL113537 | — | — | 1 | 5.17 |
| CHEMBL114796 | — | — | 1 | 5.10 |
| CHEMBL117610 | — | — | 1 | 5.07 |
| CHEMBL324614 | — | — | 1 | 4.96 |
| CHEMBL117404 | — | — | 1 | 4.80 |
| CHEMBL113886 | — | — | 1 | - |
| CHEMBL114725 | — | — | 1 | - |
| CHEMBL116979 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115812 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL331158 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL116702 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL115011 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL114724 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL326529 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL116023 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL112148 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL116900 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL323647 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL324819 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL117916 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL323652 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL424256 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL113537 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL114796 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL117610 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL324614 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL117404 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL113886 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL114725 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL116979 | — | IC50 | > | 50000.0 | nM | - |