Assay Detail
Binding
CHEMBL695137
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Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Stomach |
| Cell Type | SNU-16 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.46 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.27 |
| CHEMBL152133 | — | — | 1 | 6.76 |
| CHEMBL152543 | — | — | 1 | 6.69 |
| CHEMBL314389 | OXAMFLATIN | — | 1 | 6.63 |
| CHEMBL346525 | — | — | 1 | 6.43 |
| CHEMBL152538 | — | — | 1 | 6.24 |
| CHEMBL347068 | — | — | 1 | 6.03 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 53.29 | nM | 7.27 |
| CHEMBL152133 | — | IC50 | = | 172.02 | nM | 6.76 |
| CHEMBL152543 | — | IC50 | = | 205.27 | nM | 6.69 |
| CHEMBL314389 | OXAMFLATIN | IC50 | = | 233.15 | nM | 6.63 |
| CHEMBL346525 | — | IC50 | = | 370.97 | nM | 6.43 |
| CHEMBL152538 | — | IC50 | = | 569.97 | nM | 6.24 |
| CHEMBL347068 | — | IC50 | = | 941.61 | nM | 6.03 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2194.59 | nM | 5.66 |