Assay Detail
Binding
CHEMBL695139
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Concentration required to inhibit human Histone deacetylase (HDAC) enzyme by 50%
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.61 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.58 |
| CHEMBL140000 | — | — | 1 | 7.34 |
| CHEMBL143047 | — | — | 1 | 6.84 |
| CHEMBL167455 | — | — | 1 | 6.83 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.71 |
| CHEMBL353581 | PYROXAMIDE | 1.0 | 1 | 6.70 |
| CHEMBL162344 | — | — | 1 | 6.66 |
| CHEMBL46942 | — | — | 1 | 6.61 |
| CHEMBL164872 | — | — | 1 | 6.61 |
| CHEMBL143327 | — | — | 1 | 6.58 |
| CHEMBL162423 | — | — | 1 | 6.57 |
| CHEMBL349015 | — | — | 1 | 6.55 |
| CHEMBL165162 | — | — | 1 | 6.51 |
| CHEMBL149606 | — | — | 1 | 6.45 |
| CHEMBL143734 | — | — | 1 | 6.43 |
| CHEMBL349646 | — | — | 1 | 6.35 |
| CHEMBL146202 | — | — | 1 | 6.29 |
| CHEMBL57107 | — | — | 1 | 6.25 |
| CHEMBL139999 | — | — | 1 | 5.81 |
| CHEMBL2000089 | TRAPOXIN B | — | 1 | - |
| CHEMBL164088 | — | — | 1 | - |
| CHEMBL142305 | — | — | 1 | - |
| CHEMBL163039 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL140000 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL143047 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL167455 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL353581 | PYROXAMIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL162344 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL46942 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL164872 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL143327 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL162423 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL349015 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL165162 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL149606 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL143734 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL349646 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL146202 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL57107 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL139999 | — | IC50 | = | 1556.0 | nM | 5.81 |
| CHEMBL2000089 | TRAPOXIN B | IC50 | < | 5.0 | nM | - |
| CHEMBL164088 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL142305 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL163039 | — | IC50 | > | 10000.0 | nM | - |