Assay Detail
Binding
CHEMBL695140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against human histone deacetylase (HDAC) using HeLa nuclear extract
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Thiol-based SAHA analogues as potent histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.25 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112234 | — | — | 1 | 7.14 |
| CHEMBL320323 | — | — | 1 | 7.12 |
| CHEMBL112105 | — | — | 1 | 7.10 |
| CHEMBL113421 | — | — | 1 | 7.07 |
| CHEMBL113159 | — | — | 1 | 7.00 |
| CHEMBL332246 | — | — | 1 | 6.96 |
| CHEMBL419758 | — | — | 1 | 6.77 |
| CHEMBL322504 | — | — | 1 | 6.68 |
| CHEMBL325676 | — | — | 1 | 6.68 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.55 |
| CHEMBL112364 | — | — | 1 | 6.44 |
| CHEMBL109654 | — | — | 1 | 6.43 |
| CHEMBL112129 | — | — | 1 | 6.21 |
| CHEMBL324126 | — | — | 1 | 6.21 |
| CHEMBL112311 | — | — | 1 | 5.96 |
| CHEMBL325675 | — | — | 1 | 5.92 |
| CHEMBL326433 | 8-MERCAPTO-OCTANOIC ACID PHENYLAMIDE | — | 1 | 5.82 |
| CHEMBL114344 | — | — | 1 | 5.21 |
| CHEMBL113537 | — | — | 1 | 5.17 |
| CHEMBL111806 | — | — | 1 | 5.15 |
| CHEMBL109796 | — | — | 1 | 4.96 |
| CHEMBL114237 | — | — | 1 | 4.85 |
| CHEMBL324053 | — | — | 1 | - |
| CHEMBL111805 | — | — | 1 | - |
| CHEMBL112539 | — | — | 1 | - |
| CHEMBL112870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112234 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL320323 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL112105 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL113421 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL113159 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL332246 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL419758 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL322504 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL325676 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL112364 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL109654 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL112129 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL324126 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL112311 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL325675 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL326433 | 8-MERCAPTO-OCTANOIC ACID PHENYLAMIDE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL114344 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL113537 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL111806 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL109796 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL114237 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL324053 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL111805 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL112539 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL112870 | — | IC50 | > | 100000.0 | nM | - |