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Assay Detail

CHEMBL695144

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Binding
Inhibitory concentration against human Histone deacetylase in Hela cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HeLa
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Histone deacetylase inhibitors.
Miller TA, Witter DJ, Belvedere S.
J Med Chem (2003) 46 : 5097 -5116
PubMed 14613312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 8.52 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2371007 1 9.70
CHEMBL2370998 1 9.52
CHEMBL2371000 1 9.40
CHEMBL430060 APICIDIN 1 9.00
CHEMBL2371003 1 9.00
CHEMBL2371004 1 8.15
CHEMBL2370999 1 7.82
CHEMBL2371005 1 7.13
CHEMBL2371002 1 6.96
CHEMBL2371006 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2371007 IC50 = 0.2 nM 9.70
CHEMBL2370998 IC50 = 0.3 nM 9.52
CHEMBL2371000 IC50 = 0.4 nM 9.40
CHEMBL430060 APICIDIN IC50 = 1.0 nM 9.00
CHEMBL2371003 IC50 = 1.0 nM 9.00
CHEMBL2371004 IC50 = 7.0 nM 8.15
CHEMBL2370999 IC50 = 15.0 nM 7.82
CHEMBL2371005 IC50 = 74.0 nM 7.13
CHEMBL2371002 IC50 = 110.0 nM 6.96
CHEMBL2371006 IC50 < 0.1 nM -