Assay Detail
Functional
CHEMBL695153
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.94 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86522 | — | — | 1 | 9.08 |
| CHEMBL26116 | — | — | 1 | 8.90 |
| CHEMBL314438 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86522 | — | Kd | = | 0.8318 | nM | 9.08 |
| CHEMBL26116 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL314438 | — | Kd | = | 1.413 | nM | 8.85 |