Assay Detail
Functional
CHEMBL695155
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Compound was tested for the contractile effects antagonized by mepyramine (1-1000 nM) against Histamine H1 receptor of guinea pig aorta.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 9.02 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 9.11 |
| CHEMBL24665 | — | — | 1 | 9.01 |
| CHEMBL88075 | — | — | 1 | 9.01 |
| CHEMBL313301 | — | — | 1 | 8.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90 | HISTAMINE | Kd | = | 0.7762 | nM | 9.11 |
| CHEMBL24665 | — | Kd | = | 0.9772 | nM | 9.01 |
| CHEMBL88075 | — | Kd | = | 0.9772 | nM | 9.01 |
| CHEMBL313301 | — | Kd | = | 1.148 | nM | 8.94 |