Assay Detail
Functional
CHEMBL695207
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In vitro concentration required to reduce cell number to 50% in human colon carcinoma (HT-29) culture
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, antitumor activity, molecular modeling, and DNA binding properties of a new series of imidazonaphthalimides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.72 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31400 | ELINAFIDE | 2.0 | 1 | 7.77 |
| CHEMBL155277 | — | — | 1 | 6.50 |
| CHEMBL346936 | — | — | 1 | 6.03 |
| CHEMBL346775 | — | — | 1 | 5.97 |
| CHEMBL155828 | — | — | 1 | 5.51 |
| CHEMBL349766 | — | — | 1 | 5.42 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.33 |
| CHEMBL349765 | — | — | 1 | 5.07 |
| CHEMBL350454 | — | — | 1 | 4.82 |
| CHEMBL347567 | — | — | 1 | 4.76 |
| CHEMBL154953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31400 | ELINAFIDE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL155277 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL346936 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL346775 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL155828 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL349766 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL349765 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL350454 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL347567 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL154953 | — | IC50 | > | 100000.0 | nM | - |