Assay Detail
Functional
CHEMBL695208
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxic activity against colon adenocarcinoma (HT-29) cells assayed by inhibition of [3H]-labeled thymidine incorporation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.46 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 11.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.80 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.52 |
| CHEMBL138287 | — | — | 1 | 5.32 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.21 |
| CHEMBL140357 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL138287 | — | IC50 | = | 4755.0 | nM | 5.32 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL140357 | — | IC50 | = | 12170.0 | nM | 4.92 |